Summary:
OPTIMUM is a research study for participants 60 and older with difficult to treat depression.
- Eligible participants are randomized to medication options:
- STEP 1: (for 10 weeks) Adding aripiprazole or bupropion to currentantidepressant; or switch to bupropion
- STEP 2: (for 10 weeks) Adding lithium to current antidepressant; or switch to nortriptyline
Protocol ID:IRB#16-001829 UCLA IRB Approved Approval Date: 6/6/2017 Through: 11/30/2017 Committee: Medical IRB 3
Qualified Participants Must:
• Be 60 years of age or older
•
Be depressed
•
Be taking an antidepressant, but not feeling better
Qualified Participants May Receive:
- The study team will assess your side effects and mood for up to 12 months
- Study psychiatrists will provide medication recommendations to your primary care physician