Qualified Participants Must:
• Adults, 18 to 65 years of age
•
One or more mild TBI’s that are a minimum of six months old and occurred on or after 9/11/2001
•
Persistent post-concussion symptoms
•
Stable on psychotropic medication if the patient is on psychotropic medication
•
Subjects must be legally responsible, speak and understand English fluently, and be able to sign their own consent documents
•
Otherwise good health
Exclusion Criteria:
•
Pulmonary disease that precludes HBOT (e.g., bronchospasm unresponsive to medication, bullous emphysema)
•
Unstable medical conditions that are contraindicated in HBOT (e.g. severe congestive heart failure or heart failure requiring hospital emergency evaluation or admission in the previous year)
•
Severe confinement anxiety (e.g., patients who require anesthesia conscious sedation for MRI)
•
Participation in another experimental trial with active intervention
•
High probability of inability to complete the experimental protocol (e.g. terminal condition or inability to complete outcome instruments)
•
Past or current history of mental retardation (baseline FSIQ 70)
•
Active cancer, undergoing treatment.
Qualified Participants May Receive:
Cognitive testing, fill out questionnaires, a physical exam, and 40 daily (once/day, 5d/week, M-F) hyperbaric oxygen treatments in a standard hyperbaric chamber. Subjects will also undergo urine drug testing for drugs of abuse at each testing session and women of child-bearing potential will be urine pregnancy tested at the beginning, mid-point, and end of hyperbaric oxygen treatment.