The purpose of this study is to determine whether embryo mechanical properties measured
after in vitro fertilization can predict clinical pregnancy.
In the current practice of in vitro fertilization (IVF), clinicians often transfer multiple
embryos to the patient at once in an effort to maximize chances of pregnancy. This practice
results in a high rate of multiple births which increase the risks of complications for
mothers and children.
The investigators in this study have developed a novel, noninvasive marker of embryo
viability which is based on measuring embryo mechanical properties at the 1-cell stage. The
investigators would like to test whether human embryo mechanical properties are predictive
of clinical pregnancy, and compare their predictive power to that of a morphological
assessment (the current gold standard). Using this approach, clinicians could more
confidently move toward single embryo transfer as well as improve pregnancy rates after IVF.
This is a pilot observational study. Although investigators will measure the mechanical
properties of all participant embryos, no prediction of embryo viability will be made, and
there will be no intervention in choosing which embryos to transfer to participants. The
data from this study will eventually be used to find a range of embryo mechanical parameters
which are predictive of high developmental potential, and will serve as the basis for an
interventional study in the future.
- Between the ages of 21 and 45
- Undergoing IVF or intra-cytoplasmic sperm injection (ICSI) at Stanford between August
2015 and April 2016
- Using gestational carrier or donor eggs
- Using cryopreserved eggs
- Fewer than 5 fertilized embryos at the time of fertilization check