Stanford, California 94305


Purpose:

The purpose of this study is to determine whether embryo mechanical properties measured after in vitro fertilization can predict clinical pregnancy.


Study summary:

In the current practice of in vitro fertilization (IVF), clinicians often transfer multiple embryos to the patient at once in an effort to maximize chances of pregnancy. This practice results in a high rate of multiple births which increase the risks of complications for mothers and children. The investigators in this study have developed a novel, noninvasive marker of embryo viability which is based on measuring embryo mechanical properties at the 1-cell stage. The investigators would like to test whether human embryo mechanical properties are predictive of clinical pregnancy, and compare their predictive power to that of a morphological assessment (the current gold standard). Using this approach, clinicians could more confidently move toward single embryo transfer as well as improve pregnancy rates after IVF. This is a pilot observational study. Although investigators will measure the mechanical properties of all participant embryos, no prediction of embryo viability will be made, and there will be no intervention in choosing which embryos to transfer to participants. The data from this study will eventually be used to find a range of embryo mechanical parameters which are predictive of high developmental potential, and will serve as the basis for an interventional study in the future.


Criteria:

Inclusion Criteria: - Between the ages of 21 and 45 - Undergoing IVF or intra-cytoplasmic sperm injection (ICSI) at Stanford between August 2015 and April 2016 Exclusion Criteria: - Using gestational carrier or donor eggs - Using cryopreserved eggs - Fewer than 5 fertilized embryos at the time of fertilization check


NCT ID:

NCT02530892


Primary Contact:

Principal Investigator
Valerie Baker, MD
Stanford University

Oshra Sedan, PhD
Phone: 6504987911
Email: osedan@stanford.edu


Backup Contact:

Email: liviaz@stanford.edu
Livia Zarnescu, MS
Phone: 6504646490


Location Contact:

Stanford, California 94305
United States

Valerie Baker, MD
Phone: 650-723-3861
Email: vlbaker@stanford.edu

Site Status: Recruiting


Data Source: ClinicalTrials.gov

Date Processed: November 18, 2017

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