Expired Study
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Atlanta, Georgia 30308


Purpose:

The purpose of the study is to examine the effects of cognitive-based compassion training (CBCT), a meditative practice based on Buddhist teachings, on long term emotional well-being and immune system improvement with people living with Human Immunodeficiency Virus (PLHIV).


Study summary:

The proposed study will investigate the efficacy of cognitive-based compassion training (CBCT), a contemplative technique based on the Tibetan Buddhist tradition of compassion meditation, for enhancing immune restoration and psychological resilience in people living with HIV-1 (PLHIV). Psychosocial stress has been associated with increased circulating concentrations of key inflammatory biomarkers. The patients with HIV must cope with the physical impact of HIV disease itself, the often complex treatment regimens and side effects of combination antiretroviral therapy (ART), illness-associated psychological and existential dilemmas, changes in social roles and lifestyle patterns relative to illness progression, social stigma, and financial and material resource concerns. This study aims to determine if engagement with CBCT is associated with reduced circulating concentrations of stress-related inflammatory biomarkers, improves HIV-related clinical outcomes and decreases stress in PLHIV.


Criteria:

Inclusion Criteria: 1. Subjects living with HIV-1 infection who have been on continuous ART for a minimum of 12 months and: - are followed longitudinally for their HIV healthcare at the Infectious Disease Program - meet criteria for immunological non-responsiveness as defined by adherence to ART and cluster of differentiation 4 (CD4) count <350 cells/μL despite complete virologic suppression (> 2 plasma HIV viral load (pVL) below the limit of detection including the most recent pVL prior to enrollment). 2. Ability to give informed consent. 3. Score at least 1 standard deviation above socioeconomic status (SES)-matched general population norms on Perceived Stress Scale (PSS) Exclusion Criteria: 1. History of psychosis 2. HIV-related neurocognitive decline 3. Substance abuse within the last year 4. Documented history of cirrhosis or a total bilirubin ≥ 2.0 mg/dL 5. Known or possible pregnancy or attempting to become pregnant 6. BMI below 17 or above 30 7. Age < 18 8. Bipolar disorder 9. Bleeding disorders such as thrombocytopenia or significant gastrointestinal bleeding within the past year 10. Continuous ART for < 12 months


NCT ID:

NCT02395289


Primary Contact:

Principal Investigator
Mehul Tejani, MD
Emory University


Backup Contact:

N/A


Location Contact:

Atlanta, Georgia 30308
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: November 22, 2017

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