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Kirkland, Washington 98034


Purpose:

A Cross- Sectional study; To assess the intra-rater and inter-rater reliability of a hand-held dynamometer (HHD) in the assessment of lower extremity strength in patients with multiple sclerosis


Study summary:

Patients will be tested at two visits separated by 1-21 days. At each visit, the patients would undergo bilateral lower extremity strength assessment by two physical therapists, independently and in the same order. Testing would include: hip flexion, knee extension, knee flexion, ankle dorsiflexion Testing performed with 1) HHD (three trials recording maximum voluntary force) and 2) manual muscle testing (MMT), British Medical Research Council grade 0-5)


Criteria:

Inclusion Criteria: - Stable patients with clinically definite MS, aged ≥18, EDSS of 0-7.5 - Clinical stability defined as no MS exacerbation or change in disease modifying therapy for 30 days prior to screening. - EDSS as described above Exclusion Criteria: Contraindications to Strength testing: - Inflammatory myopathy - Endocarditis, pericarditis or other unstable heart disease - Cardiac surgery or myocardial infarction in the last 3 months - Decompensated congestive heart failure - Severe aortic stenosis - Severe pulmonary hypertension - Pulmonary embolus or infarction in the last 6 months - Uncontrolled hypertension by history or by screening or baseline diastolic blood pressure >170, or systolic blood pressure > 105) - Marfan's syndrome - Pacemaker or cardiac defibrillator - Concomitant neurodegenerative neurological disease, such as ALS or Parkinson Disease or hemiplegic stroke - Females who are pregnant - Cognitive deficits that would interfere with the subject's ability to give informed consent or perform study testing. - Anticipated treatment with Novantrone (mitoxantrone) or cancer chemotherapy or surgical procedure during the study period - Painful orthopedic condition affecting the lower extremities - Any other serious and/or unstable medical condition


NCT ID:

NCT02369224


Primary Contact:

Principal Investigator
Theodore R Brown, MD
MS Center at Evergreen


Backup Contact:

N/A


Location Contact:

Kirkland, Washington 98034
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: November 22, 2017

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