The purpose of this study is to evaluate the safety and efficacy of ocular iontophoresis with
dexamethasone phosphate ophthalmic solution EGP-437 using the EyeGate® II Drug Delivery
System (EGDS) compared to prednisolone acetate ophthalmic suspension (1%) in patients with
non-infectious anterior segment uveitis.
This will be a Phase 3, randomized, double-masked, parallel arm, positive-controlled
non-inferiority study, in which up to 250 subjects (approximately 125 subjects per treatment
arm) will be enrolled at up to 60 clinical sites. Patients with non-infectious anterior
segment uveitis who are interested in participating in the study will be provided an informed
consent form prior to screening. Screening/Baseline procedures which include BCVA, slit lamp
examination, fundus exam, IOP by tonometry will be used to determine eligibility.
1. Age 12 to 85 years with a diagnosis of non-infectious anterior segment uveitis defined
as an AC cell count of ≥ 11 cells
2. Receive, understand, and sign a copy of the written informed consent form
3. Be able to return for all study visits and willing to comply with all study-related