Expired Study
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New York, New York 10032


Purpose:

This is a randomized, open-label pilot study to assess whether treatment with chlorhexidine mouthwash can alter the esophageal and gastric cardia microbiome


Study summary:

Patients scheduled for upper endoscopy for clinical indications will be randomized to 3 weeks of either no treatment or use of twice daily chlorhexidine mouthwash leading up to the endoscopy. There will be 2-3 study visits, at Day 0 and Day 21, and for those subjects in the mouthwash arm, a final visit 1-2 weeks following the Day 21 visit. Subjects will be required to fast overnight prior to the visits on Days 0 and 21.


Criteria:

Inclusion Criteria: - Age >18 - Scheduled for upper endoscopy for clinical indications - No allergy or other contraindication to chlorhexidine Exclusion Criteria: - Use of proton pump inhibitors or H2 receptor antagonists within 1 month of enrollment. Acid suppressant medications raise the gastric pH and can dramatically alter the gastric and esophageal microbiome. - History of upper gastrointestinal cancer - History of histologically proven Barrett's esophagus - History of antireflux or bariatric surgery, or other gastric or esophageal surgery - Use of antimicrobial mouthwash within 1 month of enrollment - Use of antibiotics or immunosuppressant medications within 3 months of enrollment - Use of steroid inhalers or nasal sprays within 1 month of enrollment - HIV or other immunosuppressed states or conditions (e.g. active malignancy) - Pregnant or breast feeding - Inability to give informed consent


NCT ID:

NCT02513784


Primary Contact:

Principal Investigator
Julian A. Abrams, MD, MS
Assistant Professor of Medicine and Epidemiology


Backup Contact:

N/A


Location Contact:

New York, New York 10032
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: November 17, 2017

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