Boston, Massachusetts 02115


Purpose:

The purpose of this trial is to test the hypothesis that a treatment diet low in omega-6 fatty acids and high in omega-3 fatty acids can cause improvement in asthma symptoms, nasal symptoms, and pulmonary function in patients with aspirin-exacerbated respiratory disease (AERD).


Criteria:

Inclusion Criteria: - History of physician-diagnosed asthma - History of nasal polyposis - History of at least two reactions to oral aspirin or other nonselective cyclooxygenase inhibitor with features of lower airway involvement (cough, chest tightness, wheezing, dyspnea), or diagnosis of AERD via a physician-conducted challenge to aspirin - Age between 18 and 70 years Exclusion Criteria: - Current smoking, defined as daily tobacco smoking in the last 6 months and at least one instance of tobacco smoking in the last 3 months. - Current pregnancy or breastfeeding - BMI <20 - History of allergy to fish or any unwillingness to eat fish as a regular part of the diet - Use of Zyflo (zileuton) in the last two weeks - Presence of an implantable cardioverter-defibrillator - Use of oral steroids in the last two weeks - Participation in any other clinical trial in the last month - Any use of nonsteroidal antiinflammatory drugs (NSAIDs) or any drug that inhibits the cyclooxygenase enzyme during the course of the study


NCT ID:

NCT02064738


Primary Contact:

Principal Investigator
Tanya M Laidlaw, MD
Brigham and Women's Hospital

Tanya M Laidlaw, MD
Phone: 6175251034
Email: tlaidlaw@partners.org


Backup Contact:

Email: trschneider@partners.org
TJ Schneider
Phone: 6175251267


Location Contact:

Boston, Massachusetts 02115
United States

Tanya M Laidlaw, MD
Phone: 617-525-1034
Email: tlaidlaw@partners.org

Site Status: Recruiting


Data Source: ClinicalTrials.gov

Date Processed: November 20, 2017

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