Boston, Massachusetts 02115


The purpose of this trial is to test the hypothesis that a treatment diet low in omega-6 fatty acids and high in omega-3 fatty acids can cause improvement in asthma symptoms, nasal symptoms, and pulmonary function in patients with aspirin-exacerbated respiratory disease (AERD).


Inclusion Criteria: - History of physician-diagnosed asthma - History of nasal polyposis - History of at least two reactions to oral aspirin or other nonselective cyclooxygenase inhibitor with features of lower airway involvement (cough, chest tightness, wheezing, dyspnea), or diagnosis of AERD via a physician-conducted challenge to aspirin - Age between 18 and 70 years Exclusion Criteria: - Current smoking, defined as daily tobacco smoking in the last 6 months and at least one instance of tobacco smoking in the last 3 months. - Current pregnancy or breastfeeding - BMI <20 - History of allergy to fish or any unwillingness to eat fish as a regular part of the diet - Use of Zyflo (zileuton) in the last two weeks - Presence of an implantable cardioverter-defibrillator - Use of oral steroids in the last two weeks - Participation in any other clinical trial in the last month - Any use of nonsteroidal antiinflammatory drugs (NSAIDs) or any drug that inhibits the cyclooxygenase enzyme during the course of the study



Primary Contact:

Principal Investigator
Tanya M Laidlaw, MD
Brigham and Women's Hospital

Tanya M Laidlaw, MD
Phone: 6175251034

Backup Contact:

TJ Schneider
Phone: 6175251267

Location Contact:

Boston, Massachusetts 02115
United States

Tanya M Laidlaw, MD
Phone: 617-525-1034

Site Status: Recruiting

Data Source:

Date Processed: March 16, 2018

Modifications to this listing: Only selected fields are shown, please use the link below to view all information about this clinical trial.

Click to view Full Listing

If you would like to be contacted by the clinical trial representative please fill out the form below.