The purpose of this study is to investigate how healthy youth and adults' cortisol levels
and other hormone levels relate to anxiety levels while they participate in a behavioral
task called the Trier Social Stress Task.
Data from these healthy participants will also be compared to those of anxious youth and
adults collected as part of the in the Principal Investigator's ongoing study titled,
"Child/Adolescent Anxiety Multimodal Extended Long-term Study (NA00035687)."
The aim of this study is to investigate the independent and interactive associations linking
salivary cortisol (a marker of hypothalamic-pituitary-adrenal activity or HPA activity) and
alpha amylase (a marker of autonomic nervous system activity or ANS activity) in a sample of
healthy controls. Data from these healthy controls will be compared in the future to
clinically anxious youth. In this study, participants are asked to complete a one-time
assessment consisting of interviews, questionnaires, and a behavioral task (called the Trier
Social Stress Task) involving a short public speaking task and an arithmetic task in front
of study staff. Throughout the behavioral task, study staff will collect four, small saliva
samples using a straw-like tube from each participant. The assessment will take
approximately 3 hours. Participants will be fully debriefed regarding the purposes of the
stress procedure and assessed for any signs of residual distress. Since there is no
treatment or randomization, blinding of study staff is not applicable. Participation in this
study will not affect any current or future medical or psychiatric treatment.
AIMS: To examine whether a) salivary cortisol and alpha amylase response and recovery to the
Trier Social Stress Task is associated with anxiety in non-psychiatrically ill participants.
- Participant has no current psychiatric disorder
- Participant has no past psychiatric disorder
- Participant has no major medical disorder
- Participant is not currently receiving psychological or psychopharmacological
treatment (medication) for any psychological disorder
- Participant is between the ages 11 and 34
- Participant has or has had psychiatric disorder or medical condition contraindicating
- Participant is pregnant
- Participant is not an English speaker
- Participant has a visual, motor, or hearing problem that would affect participation