Irregular menstrual cycles are common in girls for several years after their first menstrual
period. The cause of abnormal menstrual cycles during this time is not well-understood. The
purpose of this study is to: 1) monitor girls during a menstrual cycle (with blood and urine
sampling and serial pelvic ultrasounds) to identify those girls who do not ovulate (release
of an egg from the ovary), and 2) determine whether cycles can be corrected by treating
girls with a short course of low-dose estrogen and progesterone.
- no more than 3 ½ years postmenarchal
- Subjects currently on or previously treated with medications that may affect
reproductive hormones (eg birth control pills).
- Subjects with severe acne or hirsutism
- Subjects who exercise excessively (running > 20 miles/week or its equivalent)
- Subjects with any of the following medical conditions: diabetes, hypertension,
hyperlipidemia, valvular heart disease, lupus, rheumatoid arthritis, migraine
headaches with aura, undiagnosed breast mass, inflammatory bowel disease, gallbladder
disease, sickle cell disease, or thrombophilia.
- Current smoker
- History of deep venous thrombosis or pulmonary embolism in subject or first-degree