The purpose of this research study is to evaluate the use of NAC in the treatment of anosmia
(a loss of the sense of smell). This drug is already approved by the Food and Drug
Administration (FDA) for oral or pulmonary (lung) inhaled use for other medical conditions.
However, there is research evidence that the medication may promote nerve recovery (help
nerves work better after they are damaged). Since anosmia involves nerve problems, we believe
the nasal spray may help treat anosmia. The medication has been in use for many years for
other conditions, without safety problems.
- adults at least 18 years of age with documented microsmia or anosmia by University of
Pennsylvania Smell Identification Test.
- patients must have no evidence of active sinonasal disease by nasal endoscopy or CT or
- negative CT or MRI
- adults unable to consent
- individuals who are not yet adults (infants, children, teenagers)
- pregnant women, prisoners, employees or subordinates,
- patients with known sensitivity to NAC or severe asthma
- patients with sinus or central disease on CT or MRI imaging.