West Haven, Connecticut 06516


Purpose:

The overall purpose of this study is to determine whether a family history of psychosis is associated with an altered cannabinoid system. This will be tested by studying individuals with and without a family history of psychosis and comparing their responses to delta 9-tetrahydrocannabinol (THC), a probe of the cannabinoid system. We hypothesize, that compared to controls with no family history of psychoses, individuals with a family history of psychoses will have an altered response to THC.


Criteria:

Inclusion Criteria FHP: - Exposure to cannabis at least once in their lifetime - Medically and psychiatrically healthy based on screening - Having one relative with a confirmed psychotic disorder Exclusion Criteria FHP: - Current or lifetime major DSM-IV Axis I disorder - Current or lifetime treatment (at least 6 months) with psychotropic medications for major psychiatric or neurological illness - Major or unstable medical illness that might impact safety of the subject in the study - Cannabis naive - IQ less than 85 - Less than a high school diploma or its educational equivalent - Pregnancy or lactation - Major current or recent (<6 weeks) psychosocial stressors. Inclusion Criteria FHN : - Exposure to cannabis at least once in their lifetime - Medically and psychiatrically healthy based on screening Exclusion Criteria FHN: - Having a family member with psychosis - Current or lifetime major DSM-IV Axis I disorder - Current or lifetime treatment (at least 6 months) with psychotropic medications for major psychiatric or neurological illness - Major or unstable medical illness that might impact safety of the subject in the study - Cannabis naive - IQ less than 85 - Less than a high school diploma or its educational equivalent - Pregnancy or lactation - Major current or recent (<6 weeks) psychosocial stressors.


NCT ID:

NCT02102113


Primary Contact:

Principal Investigator
Mohini Ranganathan, MD
Yale University

Christina Luddy, BS
Phone: 203-932-5711 ext. 4549
Email: christina.luddy@yale.edu


Backup Contact:

N/A


Location Contact:

West Haven, Connecticut 06516
United States

Christina Luddy, BS
Phone: 203-932-5711
Email: christina.luddy@yale.edu

Site Status: Recruiting


Data Source: ClinicalTrials.gov

Date Processed: November 21, 2017

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