Chicago, Illinois 60637


The purpose of this study is to determine whether antibiotics given immediately after birth alter the development of the developing preterm infant's microbiome, which may further alter overall clinical outcomes.


Inclusion Criteria for antibiotic randomization: 1. Infant must be born between the gestational ages of 28 0/7 weeks and 34 6/7 weeks -AND- 2. Infant must be born at investigator's home institution. -AND- 3. Infant must be considered to have a low risk of infection by one of the following criteria: 1. Delivered for maternal indications (Cesarean section or induction of labor for maternal health, including pre-eclampsia, placental abruption, history of intrauterine fetal demise (IUFD)/abruption, multiple gestation requiring preterm delivery, etc) -OR- 2. Delivered due to preterm labor to a mother without the diagnosis of chorioamnionitis/maternal fever or prolonged rupture of membranes >18 hours Exclusion Criteria for antibiotic randomization: 1. Signs of clinical illness within the first 3 hours of life: 1. 5-minute Apgar <5 2. Requiring vasoactive drugs 3. Seizures 4. Significant respiratory distress requiring supplemental oxygen >40% 2. Immature:Total (I:T) Ratio of >0.2 on initial complete blood count (CBC) 3. Congenital anomalies, including renal anomalies requiring serum antibiotic level monitoring ANY infant born between the gestational ages of 28 0/7 weeks and 34 6/7 weeks who do not meet inclusion criteria, with parental consent, can participate in the stool analysis only arm of the study.



Primary Contact:

Nicole Grady, MD
Phone: 773-702-6210

Backup Contact:

Erika Claud, MD
Phone: 773-702-6210

Location Contact:

Chicago, Illinois 60637
United States

There is no listed contact information for this specific location.

Site Status: Recruiting

Data Source:

Date Processed: March 16, 2018

Modifications to this listing: Only selected fields are shown, please use the link below to view all information about this clinical trial.

Click to view Full Listing

If you would like to be contacted by the clinical trial representative please fill out the form below.