New York, New York 10021


Purpose:

In this proposed research study, the investigators plan to assess the efficacy of gametes' (egg and sperm) treatment on fertilization as well as pre- and post-implantation embryo development.


Study summary:

The spermatozoa will be prepared in the standard fashion and utilized for injection after exposure to a membrane permeabilizing agent. The injected oocytes will be then exposed to the previously mentioned activating agents for the purpose of inducing embryo development. The successfully fertilized oocytes will be further kept in culture for up to 5 days as per standard IVF/ICSI. Results in terms of fertilization and embryo cleavage will be assessed and monitored for the remainder of the culture period. Developing embryos selected according to standard criteria will be replaced to the patient or will be cryopreserved. Because fertilization failure carries such a high emotional and financial toll on our patients, at the present time, the only method to generate an embryo for these cases is to perform assisted oocyte activation in conjunction with ICSI. The research intervention - assisted oocyte activation - is believed to help alleviate the failed fertilization by obtaining some zygotes for the patient. In these cases of complete failed fertilization, intracytoplasmic sperm injection (ICSI) will be performed as a routine clinical treatment even if they are not enrolled in the study. After several failures, their reproductive physician may recommend the use of donor spermatozoa instead of the male partner's.


Criteria:

Inclusion Criteria: - Patients with complete fertilization failure with standard IVF or failure with one prior ICSI treatment cycle Exclusion Criteria: - not meeting inclusion criteria - IVF without ICSI


NCT ID:

NCT01944332


Primary Contact:

Principal Investigator
Gianpiero Palermo, MD, PhD
Weill Medical College of Cornell University

Rodriq Stubbs, NP
Phone: 646-962-3276
Email: res2011@med.cornell.edu


Backup Contact:

Email: mij2008@med.cornell.edu
Mitasha Joseph-Sohan, RN, MPA
Phone: 646-962-3382


Location Contact:

New York, New York 10021
United States

Rodriq Stubbs, NP
Phone: 646-962-3276
Email: res2011@med.cornell.edu

Site Status: Recruiting


Data Source: ClinicalTrials.gov

Date Processed: November 21, 2017

Modifications to this listing: Only selected fields are shown, please use the link below to view all information about this clinical trial.


Click to view Full Listing

If you would like to be contacted by the clinical trial representative please fill out the form below.