The purpose of this study is to determine whether application of an incisional wound Prevena
trademark (TM) dressing (applies negative pressure to wounds) in the obese (BMI ≥30)
surgical patient will reduce surgical site infections (SSI) when compared to the standard of
In an attempt to decrease wound infection incidence and improve healing time of open
surgical wounds, vacuum assisted closure (VAC) was developed. This innovative technique
provided contained controlled wound irrigation without bacterial aerosolization. A newer
customizable subset of the Prevena incision Management System TM called Prevena Peel and
Place TM has been released a few months ago. The new model can be cut to specific wound
sizes and has a connector that can be attached to the already widely available VAC machines.
The versatility and the comparability to older models of Prevena Peel and Place TM have not
been tested to this date.
The investigators believe that a randomized clinical trial evaluating the use of the Prevena
Incision Management System TM for homecare and the use of Prevena Peel and Place TM for
inpatients in special populations is warranted. Obese patients (BMI≥30) undergoing open
surgery will have decreased surgical site infection rates, improved healing time, better
quality of life (QOL) and lower readmission rates with use of Prevena in the post-operative
management of surgical incisions.
- Patient has been informed of the nature of the study, and has provided written
informed consent, approved by the appropriate Institutional Review Board (IRB) /
Medical Ethics Committee (MEC) of the respective clinical site.
- Patient meets the criteria for and is undergoing open surgery at Johns Hopkins
- Patient with BMI≥ 30 at the time of surgery
- Patient agrees to return for all required clinical follow up for the study.
- Known allergic reaction to acrylic adhesives or silver.
- Known history of intolerance to any component of Prevena Incision Management System
- Very fragile skin around incision site.
- Bleeding disorder or refuses blood transfusion.
- Malignancy or other condition limiting life expectancy to <5 years.
Kimberley Steele, MD, PHD
Johns Hopkins University
Tammam Obeid, MBBS