Seattle, Washington 98195


Purpose:

The goal of this study is to validate that Dual Energy CT (DECT) urography when performed with a 50% reduction in iodinated contrast dose results in a CT exam with equal or better image quality and equal or better diagnostic capability compared to traditional Single Energy CT (SECT) performed with a standard contrast dose.


Study summary:

The investigators hypothesize that DECT urography performed with a 50% iodine dose reduction is equivalent to SECT urography performed with a full iodine dose for: - Enhancement of the aorta, renal arteries, and renal veins - Enhancement of the renal cortex - Enhancement of the renal pelvis, ureters, and bladder - Subjective evaluation of image quality - Objective evaluation of image quality In addition, the investigators hypothesize that DECT virtual non-contrast images using material suppression from the same low iodine CT exam results in equivalent diagnostic information compared to SECT true non-contrast images obtained in the same patient during the same exam. If the true non-contrast images could be replaced by the virtual non-contrast images without loss of information, there is potential for DECT to both significantly lower radiation dose as well as significantly decreasing iodine dose. The investigators designed this research protocol to prospectively test these hypotheses in a population scanned with a 50% reduced iodine DECT urography protocol compared to a control population scanned with a standard iodine dose clinical SECT urography protocol.


Criteria:

Inclusion Criteria: - Age >50 - Outpatient scheduled to have a CT urography at the site Exclusion Criteria: - Severe allergy to iodine containing contrast - Pregnancy (which is very unlikely for those over 50) - Body mass index (BMI) over 35 kg/m2 - Inability to provide informed consent - Inpatient


NCT ID:

NCT02283307


Primary Contact:

Janet Busey, MS
Phone: 206-543-4127
Email: jbonny@uw.edu


Backup Contact:

N/A


Location Contact:

Seattle, Washington 98195
United States

Janet Busey, MS
Phone: 206-543-4127
Email: jbonny@uw.edu

Site Status: Recruiting


Data Source: ClinicalTrials.gov

Date Processed: November 22, 2017

Modifications to this listing: Only selected fields are shown, please use the link below to view all information about this clinical trial.


Click to view Full Listing

If you would like to be contacted by the clinical trial representative please fill out the form below.