The purpose of this is that the researcher can use low power Near Infrared laser treatment
non-painful and non-damaging dose to changes the skin properties.The researcher can prove
that signaling and a significant increase in the number of skin cells in skin tissue exposed
to the laser can improve the human skin immune system to help improve human body response to
The researcher can use low power laser light one-minute exposures delivered to the skin at
non-painful and non-damaging dose. The resulted in significant immunologic changes in the
skin that included up-regulation of specific skin tissue and skin genes and the activation
and mobilization of specific skin cells.
In the first part of the study, the researcher will make a determination of the laser
irradiance that will be tolerated. The highest irradiance the subject tolerates for 1 minute
will be identified as that subject's maximum tolerable irradiance. After all subjects are
tested, researcher will select the highest irradiance that was tolerated and use this in the
second phase of the study.
Approximately 24 hours after the first test exposures, each subject will receive a one
minute laser treatment at the maximum tolerable irradiance. Four hours later, two skin
biopsies will be collected from laser treated site a untreated.
One tissue sample will be test at UC Irvine Dept. of Dermatopathology to evaluate
microscopic skin changes, one skin sample will be delivered to Massachusetts General
Hospital to evaluate RNA and protein expression.
- Adult men and women with skin type 1 and 2
- Not pregnant
- Use of systemic steroids, topical steroids, tanning solutions and anticoagulant
- History of HIV, mentally incompetent, prisoner, alcohol or drug impairment
- Abnormal photosensitivity