The purpose of this study is to examine the acute effect of exercise on vascular function in
women with nonobstructive coronary artery disease.
Women are more likely to have nonobstructive coronary artery disease (CAD) . The purpose of
this study is to examine the acute effect of exercise on vascular function in women with
nonobstructive coronary artery disease. Endothelium-dependent and -independent dilation,
arterial stiffness and wave reflection will be measured at baseline and after walking on a
treadmill at a slow pace for 47 minutes. Endothelium-dependent dilation will be measured
using brachial artery flow-mediated dilation via high resolution ultrasonography.
Endothelium-independent dilation will be measured using brachial artery dilation to
sublingual nitroglycerin. Arterial stiffness and wave reflection will measured using
- women with non-obstructive coronary artery disease documented by coronary angiogram
- age 18 to 89 years
- use of tobacco products
- use of oral contraceptives or hormone replacement therapy
- pregnancy (positive urine pregnancy test) or lactation
- history of hepatic disease or infection with hepatitis B, C or HIV