Gainesville, Florida 32611


Purpose:

The purpose of this study is to examine the acute effect of exercise on vascular function in women with nonobstructive coronary artery disease.


Study summary:

Women are more likely to have nonobstructive coronary artery disease (CAD) . The purpose of this study is to examine the acute effect of exercise on vascular function in women with nonobstructive coronary artery disease. Endothelium-dependent and -independent dilation, arterial stiffness and wave reflection will be measured at baseline and after walking on a treadmill at a slow pace for 47 minutes. Endothelium-dependent dilation will be measured using brachial artery flow-mediated dilation via high resolution ultrasonography. Endothelium-independent dilation will be measured using brachial artery dilation to sublingual nitroglycerin. Arterial stiffness and wave reflection will measured using applanation tonometry.


Criteria:

Inclusion Criteria: - women with non-obstructive coronary artery disease documented by coronary angiogram - age 18 to 89 years Exclusion Criteria: - use of tobacco products - use of oral contraceptives or hormone replacement therapy - pregnancy (positive urine pregnancy test) or lactation - history of hepatic disease or infection with hepatitis B, C or HIV


NCT ID:

NCT02450318


Primary Contact:

Principal Investigator
Demetra Christou, PhD
University of Florida

Demetra Christou, PhD
Phone: 352-294-1746
Email: ICPL@hhp.ufl.edu


Backup Contact:

N/A


Location Contact:

Gainesville, Florida 32611
United States

Demetra Christou, PhD
Phone: 352-294-1746
Email: ICPL@hhp.ufl.edu

Site Status: Recruiting


Data Source: ClinicalTrials.gov

Date Processed: November 17, 2017

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