This prospective, longitudinal study of Chinese American immigrants will examine whether
psychosocial factors (e.g., acculturative stress, social isolation, discrimination) are
associated with markers of type 2 diabetes risk over time, and whether such associations are
mediated by inflammatory pathways.
It is now well-documented that immigration to the US leads to increased risk for various
chronic diseases, including type 2 diabetes. The increased diabetes risk observed among
Chinese immigrants has been primarily attributed to changes in diet and weight gain
following immigration, but these changes can only partially explain disparities in disease
risk. Models of immigrant health suggest that the stress of adapting to life in a new
country has a considerable impact on physical health. However, few studies have considered
the psychosocial impact of immigration upon biomarkers of health and disease risk.
Therefore, this longitudinal study of US Chinese immigrant men and women will examine: (1)
whether psychosocial factors (e.g., acculturative stress, social isolation, discrimination)
are associated with markers of type 2 diabetes risk over time; and (2) whether the
association between psychosocial factors and diabetes risk markers is mediated by
- Chinese heritage;
- migration from Asia in adulthood (aged 18 years or older); and
- age 35-65 years
- Current or prior history of diabetes
- Self-reported conditions of cancer, auto-immune disorders, HIV, or psychiatric
- Use of medications that may impact study outcomes (e.g., steroidal or non-steroidal
- Inability to provide informed consent.