Nashville, Tennessee 37212


Purpose:

The investigators will recruit and randomize 200 elective cardiac surgery patients to receive physiologic oxygenation (normoxia) or hyper-oxygenation (hyperoxia) during surgery to test the hypothesis that intraoperative physiologic oxygenation decreases the generation of reactive oxygen species, oxidative damage, and postoperative organ injury compared to hyper-oxygenation.


Criteria:

Inclusion Criteria: - Open-heart cardiac surgery, defined as surgery on the heart or aorta that requires sternotomy or thoracotomy. Exclusion Criteria: - Current acute coronary syndrome (defined as ST elevation myocardial infarction or non-ST elevation myocardial infarction (troponin leak within 72 hours of surgery or consent +/- EKG changes consistent with myocardial ischemia)). - Home supplemental oxygen use. - Preoperative supplemental oxygen requirement to maintain arterial O2 sat of 92%. - Right to left intracardiac shunt including atrial septal defect and ventricular septal defect with Cor Pulmonale. - Carotid stenosis defined as >50% stenosis. - Cardiac surgery that requires intraoperative circulatory arrest, such as aortic arch replacement. - Current use of hemo- or peritoneal dialysis. - Pregnancy


NCT ID:

NCT02361944


Primary Contact:

Principal Investigator
Frederic T. Billings, IV, MD, MSc
Vanderbilt University Medical Center


Backup Contact:

N/A


Location Contact:

Nashville, Tennessee 37212
United States

Frederic T. Billings, IV, MD, MSc
Phone: 615-343-6479
Email: frederic.t.billings@vanderbilt.edu

Site Status: Recruiting


Data Source: ClinicalTrials.gov

Date Processed: November 19, 2017

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