Expired Study
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Boston, Massachusetts 02118


Purpose:

The study will compare the effectiveness of amitriptyline versus placebo (inactive medication) in treating chronic laryngitis. At the baseline visit, subjects will be assigned at random to amitriptyline or placebo which they will take for 8 weeks. Subjects will be seen in the clinic at baseline and at 8 weeks. Improvement will be measured using standardized symptom scales, and a self-reported subjective improvement percentage.


Criteria:

Inclusion Criteria: - Age 18 or older and able to consent for themselves. - Structural pathology such as tumor previously ruled out using flexible laryngoscopy. - Able to speak and read the English language. - Failed a trial of a proton pump inhibitor for the treatment of gastopharyngeal reflux. - Women under 55 years of age who may become pregnant must have a negative pregnancy test and agree to barrier or hormonal methods of contraception during the study. Exclusion Criteria: - Environmental allergies. - Smoking within past 5 years. - Using ginko bilboa (or unwilling to cease using it). - Current upper respiratory infections. - Use of narcotics (e.g. oxycodone, methadone). - Any prior history of amitryptiline use. - Use of monoamine oxidase inhibitors (MAOIs) within the past 4 weeks (selegiline, phenelzine, tranylcypromine, isocarboxazid, rasagiline, phenelzine sulfate, selegiline hydrochloride, rasagiline mesylate, tranylcypromine sulfate). - History of urinary retention. - Any history of major depressive disorder. - Any prior history of allergy to a tricyclic antidepressant. - Current diagnosis of gastroesophageal reflux (GERD). - For women 18-55 years of age without history of menopause: currently nursing or pregnant, plans to become pregnant, or unwillingness to utilize contraception (barrier or hormonal methods).


NCT ID:

NCT02434523


Primary Contact:

Principal Investigator
J. Pieter Noordzij, MD
Boston Medical Center


Backup Contact:

N/A


Location Contact:

Boston, Massachusetts 02118
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: November 18, 2017

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