Expired Study
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Columbus, Ohio 43214


Purpose:

The purpose of this study is to determine whether liposomal bupivacaine is effective in the management of pain following total joint arthroplasty, as compared to standard of care analgesia.


Study summary:

Liposomal bupivacaine (Exparel®) is a local anesthetic made up of liposomal encapsulated bupivacaine. It is designed to be injected at the time of surgery into the local soft tissues. Because of its unique liposomal delivery system, Liposomal bupivacaine (Exparel®) has been shown to provide up to 96 hours of pain relief following surgeries. This makes it an attractive option in total joint arthroplasty patients. Combined with the proven efficacy of regional anesthesia, intraoperative liposomal bupivacaine (Exparel®) may provide extended pain relief following total joint arthroplasty. This has the potential to avoid the need for opioid medications. With better pain control, medication side effects can be avoided and patient's length of stay in the hospital can be shortened.


Criteria:

Inclusion Criteria: 1. Clinical diagnosis of osteoarthritis 2. Elected to undergo primary TKA, THA, or TSA Exclusion Criteria: 1. Age < 18 years 2. Pregnant or breastfeeding 3. Non-English speaking 4. Unable to give informed consent 5. Previous open hip, knee or shoulder surgery 6. Pre-determined patients discharging to ECF 7. Patients with allergies to bupivacaine 8. Patients currently taking opioid pain medication 9. Patients with contraindication to nerve blocks 10. Patients undergoing simultaneous bilateral joint replacement, as this would require >1 dose of liposomal bupivacaine (Exparel®) per patient for each surgical site 11. Patients with severe hepatic disease 12. Patients with chronic heart disease as defined as a decreased ejection fraction


NCT ID:

NCT02197273


Primary Contact:

Principal Investigator
Elizabeth Brill, MD
OhioHealth


Backup Contact:

N/A


Location Contact:

Columbus, Ohio 43214
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: November 19, 2017

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