Subjects are female patients, randomized to HCG group or placebo group, during a prospective
trial, in order to determine the significance, if any, of HCG on maintaining muscle mass
during a very low calorie diet in order to demonstrate the potential significance of HCG
administration on preserving lean body mass while losing weight.
Four-week clinical trials were conducted on 59 females between the ages of 20 and 55, over
an 18 month period. Exclusion criteria included thyroid conditions or prior significant
medical history. Patients were randomized to receive daily subcutaneous injections of
either hCG (200-300IU) or saline (placebo). All were placed on a VLCD resembling a
protein-sparing modified fast. The caloric intake was between 500 and 600 calories, with
50% protein and 50% complex carbohydrates consisting mostly of fruits and vegetables.
Measured parameters: weight, body composition via bio-impedance, blood pressure, and blood
labs. A subset also underwent weekly electrocardiograms (EKG).
- Body Mass Index (BMI) greater than 30,
- good health
- complex medical history,
- thyroid disease,
- BMI less than 30,
- psychological instability or history of eating disorder