This pilot clinical trial studies quantitative magnetic resonance imaging (MRI) at 3 Tesla in
assessing disease in patients with tumors that have spread to the brain (brain metastases).
In addition to routine care brain imaging of the brain, this study will include advanced
multiparametric MRI sequences to measure vascular, cellular, and molecular properties of the
tumor. Performing extra scans during MRI provides more information about the metastases and
may better predict treatment response.
I. To correlate pre-treatment measures of biophysical parameters in metastases—obtained using
advanced, quantitative MRI techniques in patients receiving standard-of-care (SOC) therapy
for 1-4 brain metastases—with treatment-induced changes in lesion size, time-to-progression
(TTP), and overall survival (OS).
Patients undergo hybrid 3 Tesla MRI examination that includes standard MRI sequences,
diffusion-weighted (DW)-MRI, chemical exchange saturation transfer (CEST), and combined
dynamic contrast enhanced (DCE)-MRI/dynamic susceptibility contrast (DSC)-MRI at baseline.
- Patients must sign an Institutional Review Board (IRB)-approved informed consent
- Patients must have been diagnosed with one of the following:
- Primary brain tumor (glioma, GBM etc); or
- Up to 10 brain metastases
- Patients must have been diagnosed with 1-4 brain metastases
- At least one of the brain metastases must measure 5 mm (or more) in short axis
diameter in the axial plane
- Patients must be scheduled to undergo standard brain cancer interventions:
- Chemotherapy or targeted antiangiogenic therapy, in the case of primary brain
- Stereotaxic radiotherapy (SRS) or whole brain radiotherapy (WBRT), in the case of
- Patients must be scheduled to receive a 3-Tesla (3T) MRI exam as part of their
standard of care (this exam will be modified to also include pulse sequences with are
for research only)
- Patients who have received previous treatment (chemotherapy or radiotherapy) for any
brain tumor (primary or metastatic).
- Patients who are scheduled to receive a 1.5T MRI exam
- Patients incapable of giving informed written consent, due to mental disability,
altered mental status, confusion, cognitive impairment, or psychiatric disorders.
- Patients scoring 14.5 or lower on the University of California, San Diego Brief
Assessment of Capacity to Consent (UBACC) questionnaire will not be allowed on the