District of Columbia
The objective of the KAROS study is to compare rehabilitation outcomes between 3 proposed
protocols and a current standard of care protocol for the purpose of identifying better
practice for outpatient rehabilitation among patients with single total knee replacement.
The 3 advanced protocols involve use of an anti-gravity treadmill and/or the patterned
electrical neuromuscular stimulation (PENS). Both medical modalities have been cleared by
the FDA to be used in medical rehabilitation, including total knee replacement.
- Patients who undergo an elective single total knee arthroplasty and initiate their
outpatient rehabilitation therapy within 3 weeks after surgery.
- Patients who are 40 years old or older.
- Patients who weight less than 320 lb to accommodate the weight limit to use the
- Patients who had any lower extremity joint replacement less than 1 year prior the
current total knee replacement.
- Patients who are pregnant or may be pregnant.
- Patients who have a medical history of neurologic disorders.
- Patients who have received more than 2 weeks of other formats of rehabilitation prior
their outpatient rehabilitation program.
- Patients who received any cancer treatment in the past year prior the current
- Patients who have uncontrolled cardiovascular hypertension.
- Patients who have cardiac demand pacemakers and/or implanted defibrillators.