Liposomal bupivacaine is a novel local anesthetic designed for prolonged pain relief.
Despite its long-acting analgesic potential, liposomal bupivacaine is significantly more
expensive than other local anesthetic alternatives. The primary aim of this investigation is
to examine whether or not liposomal bupivacaine provides superior pain relief or clinically
significant opioid-sparing effects versus a control to justify its cost.
- Patients undergoing a primary unilateral total knee arthroplasty by the PI of the
- Patients with a sensitivity to marcaine
- Pregnant or lactating women
- Non-English speaking individuals