Rochester, Minnesota 55901


Purpose:

This study is being done because the investigators are trying to understand how feedback from the muscles can influence your blood pressure and breathing during exercise, and if the investigators can reduce this response in heart failure patients. The investigators are also trying to determine ways to improve tolerance to exercise in heart failure patients.


Study summary:

If you are enrolled in this study the investigators will ask you to make 3 separate study visits. During study visit 1 you will be asked to get a blood draw, DEXA bone scan, perform pulmonary function tests, and exercise on a stationary bike at maximal exertion while breathing into a mouth piece. During study visits 2 and 3 you will be asked to again exercise at maximal exertion while breathing into a mouth piece. However, during these two visits you will be receiving an intrathecal injection of fentanyl one day and placebo the other day, randomly selected and you will be blinded as to which you are receiving. A catheter will also be placed in an artery in your arm and a vein in your leg, which will help us to measure blood flow, blood pressure and draw blood when need be. The investigators will also ask you to perform a brief chemosensitivity test, breathing in and out your own air, after you are done exercising.


Criteria:

Inclusion Criteria (Heart Failure Patients): - History of ischemic or idiopathic dilated cardiomyopathy - New York Heart Association class 1-3 - No history of dangerous arrhythmia's - Not pacemaker dependent - Body Mass Index less than or equal to 35 kg/m - Current non-smokers with less than 15 pack year history - Non-pregnant women - Individuals who are able to exercise without orthopedic limitations - All patients will be managed by their primary care physician or cardiologist prior to enrollment to ensure inclusion and exclusion criteria have been satisfied and participation in exercise testing is safe. Control Participants: - Will be matched for age, gender, height and weight and will have no history of cardiovascular related abnormalities. - Body Mass Index less than 35 kg/m - Current non-smokers with less than 15 pack year history - Non-pregnant women - Individuals who are able to exercise without orthopedic limitations


NCT ID:

NCT02421341


Primary Contact:

Principal Investigator
Thomas Olson, PhD
Mayo Clinic

Eric Bruhn
Phone: 507-255-7125


Backup Contact:

N/A


Location Contact:

Rochester, Minnesota 55901
United States



There is no listed contact information for this specific location.

Site Status: Recruiting


Data Source: ClinicalTrials.gov

Date Processed: November 19, 2017

Modifications to this listing: Only selected fields are shown, please use the link below to view all information about this clinical trial.


Click to view Full Listing

This study is not currently recruiting Study Participants on ClinicalConnection.com. The form below is not enabled.