Expired Study
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Fort Worth, Texas 76134


The purpose of this study is to evaluate the additive intraocular pressure (IOP) lowering effect of brinzolamide 1%/brimonidine 0.2% (dosed twice per day (BID)) when added to a PGA in patients with open-angle glaucoma or ocular hypertension.

Study summary:

This study consists of 2 sequential phases: Screening/Eligibility Phase, which includes a Run-in/Washout (Phase I), and Masked Treatment Phase (Phase II). At the Screening Visit, subjects will be assigned into one of 3 PGA therapy groups for the duration of the study. Subjects previously prescribed TRAVATAN®, XALATAN®, or LUMIGAN® monotherapy with uncontrolled IOP will not need a run-in period with PGA.


Inclusion Criteria: - Diagnosis of either open-angle glaucoma or ocular hypertension; - Must sign an informed consent form; - Mean IOP measurements at both the Eligibility 1 and 2 visits, in at least 1 eye (the same eye[s]) ≥ 19 and < 32 mmHg at 09:00. - Willing and able to attend all study visits; - Other protocol-specified inclusion criteria may apply. Exclusion Criteria: - Women of childbearing potential who are pregnant, breast-feeding, intend to become pregnant during the study, or not using adequate birth control methods to prevent pregnancy throughout the study; - Any form of glaucoma other than open-angle glaucoma or ocular hypertension; - Ocular disease, trauma, infection, inflammation, pathology, or surgery as specified in the protocol; - Any other conditions including severe illness which would make the subject, in the opinion of the Investigator, unsuitable for the study; - Other protocol-specified exclusion criteria may apply.



Primary Contact:

Study Director
Clinical Manager, Ophtha, GCRA
Alcon, a Novartis Company

Backup Contact:


Location Contact:

Fort Worth, Texas 76134
United States

There is no listed contact information for this specific location.

Site Status: N/A

Data Source: ClinicalTrials.gov

Date Processed: March 16, 2018

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