St.Louis, Missouri 63110


Purpose:

To demonstrate feasibility of imaging Cu[64]-25%-CANF-Comb uptake in the atherosclerosis of the carotid artery of patients for whom carotid artery endarterectomy surgery is planned in comparison to the carotid artery for which intervention is not planned.


Study summary:

This study is a single center, open-label baseline controlled imaging study designed to demonstrate feasibility of PET imaging of radiopharmaceutical nanoparticle Cu[64]-25%CANF-Comb uptake by PET-MR. Patients will undergo Cu[64]-25%CANF-Comb PET-MR imaging of both carotid arteries. Both carotid arteries will be imaged at the same time. We hope to demonstrate differences in PET SUV (Standardized Uptake Value) in the significantly atherosclerotic artery in patients who will be going to carotid endarterectomy surgery in comparison to the PET SUV in the artery that is not significantly diseased (ie; the artery that will not undergo surgery) . We also will determine whether PET SUV of the Cu[64]-25%CANF-Comb by the plaque correlates to the American Heart Association classifications of atherosclerosis and tissue presence of NPR-C in the ex vivo carotid endarterectomy specimen post surgery as measured by RT-PCR.


Criteria:

Inclusion Criteria: - Patients with carotid atherosclerosis - Patients must be scheduled for carotid intervention (endarterectomy surgery) - Signed informed consent. Exclusion Criteria: - Unstable clinical conditions - Pregnancy and lactation - Inability to lie still for up to 60 min with arms down at sides for PET-MR imaging - Unwilling to comply with study procedures and unavailable for the duration of the study. - Pacemakers, brain aneurysm clip, shrapnel and other typical contraindications for MRI imaging. - Inability to provide written informed consent.


NCT ID:

NCT02417688


Primary Contact:

Principal Investigator
Pamela K Wooderd, MD
Washington University School of Medicine

Molly Mohrman
Phone: (314) 747-4633
Email: mohrmanm@mir.wustl.edu


Backup Contact:

Email: koudelisd@mir.wustl.edu
Deborah Koudelis, RN
Phone: (314) 747-3876


Location Contact:

St.Louis, Missouri 63110
United States

Pamela K Woodard, MD
Phone: 314-362-9989
Email: woodardp@mir.wustl.edu

Site Status: Recruiting


Data Source: ClinicalTrials.gov

Date Processed: November 24, 2017

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