Expired Study
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Philadelphia, Pennsylvania 19107


Purpose:

This pilot research trial studies patient derived cancer cell lines in identifying molecular changes in patients with previously untreated pancreatic cancer and are receiving gemcitabine hydrochloride-based chemotherapy. Cell lines refer to samples taken from the patient's tumor to grow for many months or years in a laboratory, and can therefore be studied scientifically. Studying cell lines in the laboratory may help doctors understand the genetic changes that occur to the tumor during chemotherapy that allows the tumor to resist or grow despite treatment.


Study summary:

PRIMARY OBJECTIVES: I. Compare the genetic profile of the tumor after progression has occurred, to the tumor prior to treatment. SECONDARY OBJECTIVES: I. Additional molecular patterns, beyond genetics, will be analyzed, including ribonucleic acid (RNA) and protein expression. OUTLINE: Tissue and blood samples are collected for genetic analysis via sequencing from patients receiving gemcitabine hydrochloride intravenously or gemcitabine hydrochloride and paclitaxel albumin-stabilized nanoparticle formulation. Chemotherapy is not part of the protocol. Per standard of care, patients receive gemcitabine hydrochloride (IV) the first 3 of 4 weeks (qw 3/4 wk) or gemcitabine hydrochloride and paclitaxel albumin-stabilized nanoparticle formulation IV qw 3/4 wk in the absence of disease progression or recurrence.


Criteria:

Inclusion Criteria: 1. Suspected or confirmed pancreatic adenocarcinoma, any stage 2. >18 years of age 3. No prior systemic chemotherapy for pancreatic cancer, or currently undergoing first-line treatment for pancreatic cancer, or completed only first-line treatment for pancreatic cancer 4. A plan to undergo gemcitabine-based chemotherapy at Thomas Jefferson or a collaborating institution 5. Abdominal/pelvic CT scan or MRI within 4 months of the study 6. Signed study-specific informed consent Exclusion Criteria: 1. Pregnancy 2. Prior systemic chemotherapy for pancreatic cancer 3. Gender/Minority/Pediatric Inclusion for Research


NCT ID:

NCT02414100


Primary Contact:

Principal Investigator
Jordan Winter, MD
Thomas Jefferson University


Backup Contact:

N/A


Location Contact:

Philadelphia, Pennsylvania 19107
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: November 21, 2017

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