The study objectives are the following: 1) To examine the acute vascular responses to
continuous low- and moderate-intensity exercise and interval training; and 2) To examine the
influence of age and gender on these responses.
The type, intensity and duration of exercise, fitness state, and timing of measurements have
been reported to influence the acute vascular responses to exercise. However, little is
known regarding the influence of interval training, aging and gender on these responses. The
objectives of this study are: 1) to examine the acute vascular responses to continuous low-
and moderate-intensity exercise and interval training; and 2) to examine the influence of
age and gender on these responses. Subjects will perform the following 3 types of treadmill
exercise in a random order: 1) slow-pace walking; 2) moderate-pace walking; and 3) interval
training. Flow mediated dilation using high resolution ultrasonography and arterial
stiffness using applanation tonometry will be measured before, immediately after and 1-hour
after each acute bout of exercise.
- Men and women 18 to 79 years of age
- Women will be premenopausal or postmenopausal (either natural or surgical) defined as
a cessation of menses for at least 2 years.
- Premenopausal women will be eumenorrheic.
- Able to give consent.
- History of hepatic disease or infection with hepatitis B, C or HIV
- History of other relevant on-going or recurrent illness
- Recent (within 3 months) or recurrent hospitalizations
- Current intake of medications that may affect study results
- Use of tobacco products
- Premenopausal women taking oral contraceptives and postmenopausal women taking
hormone replacement therapy.
- Pregnancy (positive urine pregnancy test) or lactation
- Perimenopausal women