Study GT-030 is a phase 2a, single-center, open-label study of subjects with moderate to
severe plaque psoriasis
The overall objective is to establish the safety and efficacy of GR-MD-02 in patients with
moderate to severe plaque psoriasis.
The objective is to evaluate the number of patients with moderate to severe plaque psoriasis
who have 75% improvement in Psoriasis Activity Severity Index (PASI-75) following 12 weeks of
therapy with GR-MD-02
- To determine the PASI-50 and PASI-100 scores in patients with moderate to severe plaque
psoriasis following the first 12 weeks of therapy with GR-MD-02
- To determine the PASI-50, PASI-75, and PASI-100 scores in patients with moderate to
severe plaque psoriasis following an additional 12 weeks of therapy (total 24 weeks)
- To determine the durability of response to therapy in responders over a one year period
following the end of therapy
- To determine whether there is any change in disease status of patients who also have
- To determine the incidence of adverse events and vital sign and laboratory abnormalities
during study treatment
Each subject must meet all of the following criteria to be enrolled in this study:
1. Is capable of understanding the written informed consent, provides signed and
witnessed written informed consent, and agrees to comply with protocol requirements.
2. Is between the ages of 18 and 75 years.
3. Has biopsy proven psoriasis and active moderate to severe plaque psoriasis with a PASI
of ≥ 12 and at least 10% of involved body surface area.
4. The patient is not pregnant and must have a negative pregnancy test prior to start of
the study. Post-menopausal women must have been amenorrheic for at least 12 months to
be considered of non-child-bearing potential.
5. Sexually active men or women of childbearing potential must agree to use effective
means of contraception throughout their participation in this study and for 90 days
after discontinuation of study medication.
6. Lactating females must agree to discontinue nursing before the start of study
treatment and refrain from nursing until 90 days after discontinuation of study
7. Male subjects must refrain from sperm donation throughout the study period and for a
period of 90 days following the last dose of study drug.
Subjects meeting any of the following criteria will be excluded from the study:
1. Any medical illness that is not stable on therapy
2. Use of any biologic medication for psoriasis within 6 months
3. Use of or non-biological systemic therapy to include: methotrexate, oral retinoids,
phototherapy/PUVA, cyclosporine, or any other cytotoxic or immunosuppressive
medication within 4 weeks of start of study
4. Topical treatment that is likely to impact signs and symptoms of psoriasis, in the
opinion of the Principal Investigator, within 2 weeks of the start of the study
5. Prior exposure to GR-MD-02
6. Known positivity for Human Immunodeficiency Virus (HIV) infection
7. Any patient who had major surgery within 8 weeks of Day 1, significant traumatic
injury, or anticipation of need for major surgical procedure during the study.
8. Has a history of alcohol/drug abuse.
9. Any patient who has clinically significant and uncontrolled cardiovascular disease
(e.g., uncontrolled hypertension, myocardial infarction, unstable angina), New York
Heart Association (NYHA) Grade II or greater congestive heart failure, serious cardiac
arrhythmia requiring medication, or Grade II or greater peripheral vascular disease
within 12 months prior to Day 1.
10. Any patient with concurrent infection including diagnoses of fever of unknown origin
(FUO) (subjects must be afebrile at the start of therapy).
11. History of malignant disease with a recurrence of that disease within 5 years of
follow-up except for those that have been curatively treated including basal or
squamous cell carcinoma of the skin and in situ carcinoma of the cervix
12. Participation in an investigational new drug (IND) trial in the 30 days before
13. Clinically significant medical or psychiatric condition considered a high risk for
participation in an investigational study.
14. Has donated or lost a significant volume (>450 mL) of blood or plasma within 30 days
of the study.
15. Failure to give informed consent
16. Subjects with known allergies to the study drug or any of its excipients.
17. Is an employee or family member of the investigator or study site personnel.