Expired Study
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Atlanta, Georgia 30303


Purpose:

The purpose of this study is to see if salsalate, an Nuclear factor-kappaB (NF-κB) mediated inflammation inhibitor, or carvedilol, an α- and β-blocker, will protect against free fatty acid induced hypertension, insulin resistance, endothelial dysfunction, inflammation and oxidative stress, and autonomic dysfunction in obese normotensive subjects.


Study summary:

During postprandial lipemia, dietary triglycerides transported by intestinal chylomicrons are hydrolyzed by lipoprotein lipase lining the vascular bed, with subsequent release of FFA for transport across the endothelium. Whether the intermittent flux of FFA has the same impact as the i.v. lipid infusion will be examined. Decreased endothelial function has been reported after a single or long-term dietary high fat load in normal subjects; however, others have found no effects on brachial artery vasoreactivity. Our preliminary studies indicate that high oral fat loads (60 g) resulted in higher FFA levels and BP changes, and reduced FMD compared to low fat load (25 g).


Criteria:

Inclusion Criteria: - Males or females - Obese subjects (body mass index (BMI) ≥ 30 kg/m^2) - 18 and 65 years - Blood pressure reading < 140/80 mm Hg and no prior history of hypertension Exclusion Criteria: - History of diabetes mellitus - History of hypertension - Fasting triglyceride levels > 250 mg/dL - Liver disease (ALT 2.5x > upper limit of normal) - Serum creatinine ≥1.5 mg/dL - Smokers, drug or alcohol abuse - Mental condition rendering the subject unable to understand the scope and possible consequences of the study - Female subjects who are pregnant or breast feeding


NCT ID:

NCT02406586


Primary Contact:

Principal Investigator
Guillermo Umpierrez, MD
Emory University


Backup Contact:

N/A


Location Contact:

Atlanta, Georgia 30303
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: March 16, 2018

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