The investigation will employ a longitudinal approach in which every fetus diagnosed to be
SGA (Small for Gestational Age ) will be studied at frequent intervals with sophisticated
imaging techniques to assess subtle physiologic changes in the brain, heart, and placenta
over time. These findings will be correlated with neurological and cardiovascular function in
the newborn and early childhood. This research initiative should yield diagnostic and
therapeutic templates that will improve the quality of life of IUGR babies in addition to
providing important information that will better inform current diagnostic practices.
The overarching objective is to serially assess changes in the fetal circulation, heart, and
brain with sophisticated ultrasound, MRI (Magnetic Resonance Imaging), and body composition
techniques that will provide clues as to how growth restricted babies will tolerate life
outside the uterus. Employing a longitudinal study will allow the investigators to correlate
perinatal and postnatal outcomes more comprehensively than previous studies.
- Patients with diagnosed SGA by an ultrasound estimated fetal weight (EFW) of less than
the 10th percentile or a fetal abdominal circumference of less than the 5th percentile
will be included in the study at the time of their first examination.
- Patients < 18 years of age, and chromosomal anomalies as identified by regular