Philadelphia, Pennsylvania 19104


Purpose:

Over 18% of Americans aged 65 years and older have depression. Recent evidence suggests that there is a link between depression and inflammatory disease. This study investigates the relationship between inflammation in the brain and depression. Comparing biological and psychological differences in depressed and non-depressed people allows researchers to find better ways to treat and prevent depression. All participants will have: neuropsychological tests, an EKG, a spinal tap, a blood draw, and, if depressed, given either an antidepressant coupled with an anti-inflammatory medication or an anti-depressant coupled with a placebo for six weeks. The investigators are trying to correlate brain function with depression levels and biomarkers from the blood and spinal fluid.


Criteria:

Inclusion Criteria: 1. Age 18-80, male or female, any race; 2. Absence of clinical dementia 3. English speaking 4. Blood pressure not exceeding 150/90 mmHg, treated or untreated 5. Weight greater than 110 lbs Additional Inclusion Criteria for Depressed Participants: 1. DSM-IV criteria for Major Depressive Disorder 2. HAM-D greater than 18 Exclusion Criteria: 1. Known history of relevant severe drug allergy or hypersensitivity (e.g. to Citalopram or Escitalopram, and/or to celecoxib, aspirin, or other NSAIDs; known demonstration of allergic-type reactions to sulfonamides); 2. Cannot give informed consent; 3. MRI contraindications (e.g., foreign metallic implants, pacemaker); 4. Known primary neurological disorders, such as Parkinson's disease, Alzheimer's disease, traumatic brain injury, cognitive impairment or dementia, 5. Have a known inflammatory disease 6. Diagnosis of a chronic psychiatric illness other than MDD; 7. Clinically significant cardiovascular disease within the last 6 months; cardiac arrythmia 8. Clinically significant abnormalities on EKG. 9. A lifetime history or current diagnosis of cancer 10. A lifetime history or current diagnosis of HIV, Hepatitis B and/or Hepatitis C 11. Use of an Investigational medicine within the past 30 days; 12. Use of Coumadin, Warfarin within the past 2 months; 13. Current treatment with psychotropic drugs or drugs that affect the Central Nervous System such as beta-blockers, mood stabilizers, antipsychotics, steroids or non-steroidal anti-inflammatory medications or other antidepressants 14. Current alcohol or substance abuse disorder, schizophrenia or other psychotic disorder, bipolar disorder, or current Obsessive Compulsive Disorder; 15. History of ulcer disease, GI bleeding or anemia 16. Currently pregnant or trying to become pregnant Additional Exclusion Criteria for Depressed Subjects: 1) Active suicidality or current suicidal risk as determined by the investigator


NCT ID:

NCT02389465


Primary Contact:

Gabriella Green, MS
Phone: 215-573-0083
Email: gabgreen@mail.med.upenn.edu


Backup Contact:

N/A


Location Contact:

Philadelphia, Pennsylvania 19104
United States

Gabriella Green, MS
Phone: 215-573-0083
Email: gabgreen@pennmedicine.upenn.edu

Site Status: Recruiting


Data Source: ClinicalTrials.gov

Date Processed: November 23, 2017

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