This study will compare genomic alterations between the parents and the patients with
Genomic changes leading to the formation of brain tumors are slowly being discovered.
Despite advances in genomic technology, much analysis is hindered by the lack of control
samples that could better delineate genomic alterations leading to disease. The ideal
genomic control would be the genetic material of the parents of afflicted individuals. The
researchers propose to then compare the genomic material from parents of siblings, both of
whom have a diagnosis of a high-grade glioma. Additionally, the researchers will then
compare the genomic alterations between the parents and the patients. This analysis will
provide an unprecedented insight into genomic level changes that take place between parents
and patients that resulted in the formation of a high-grade glioma.
- 18 years or older.
- Family history of brain tumor in first degree relative
- less than 18 years
Peter Nakaji, MD
Saint Joseph's Hospital and Medical Center/Barrow Neurological Institute
Norissa Honea, RN, PhD