The purpose of this study is to perform first-in-human PET imaging studies of two new
cardiac sympathetic nerve imaging agents, 4-[18F]fluoro-meta-hydroxyphenethylguanidine
([18F]4F-MHPG) and 3-[18F]fluoro-para-hydroxyphenethylguanidine ([18F]3F-PHPG).
In this study, PET imaging studies of two structurally related
18F-hydroxyphenethylguanidines, 4-[18F]fluoro-meta-hydroxyphenethylguanidine ([18F]4F-MHPG)
and 3-[18F]fluoro-para-hydroxyphenethylguanidine ([18F]3F-PHPG) will be performed. All
studies will be performed in normal healthy volunteers.
PET stands for Positron Emission Tomography which is a type of imaging that uses a
radioactive tracer. This is also called a radiotracer which is a compound linked to a
radioactive element. Most compounds are short-lived, meaning that the radioactivity breaks
down quickly or is excreted from the body.
In the first stage of the study, dynamic PET imaging for 90 min will be done with
[18F]4F-MHPG (n = 4) and [18F]3F-PHPG (n = 4).
Data from these studies will assess each radiotracer's imaging properties, pharmacokinetics
and metabolic breakdown in plasma. Application of tracer kinetic analysis methods to the
kinetics of each tracer in heart and plasma will be studied to see if these methods can
provide accurate measurements of regional nerve sympathetic nerve density in the hearts of
human subjects. Results from these initial studies will be used to select the lead compound
for further studies in patient populations.
In the second stage of the study, whole-body PET imaging studies (n = 4) with the selected
lead radiotracer will be performed to acquire data necessary for generating more accurate
human radiation absorbed dose estimates.
- Non-obese (BMI < 30)
- Normal blood pressure
- Normal blood lipid profile
- No history of prior cardiovascular disease
- Not susceptible to claustrophobia
- Ability to lay flat for 90 min
- Obesity (BMI > 30)
- Risk factors for heart disease (age > 55y, hypertension, smoking, high blood
pressure, high cholesterol levels, diabetes, etc.)
- History of heart disease (heart attack, atrial fibrillation, ventricular tachycardia,
- Currently using certain medications that may interact with cardiac nerves
(antidepressants, cold medications, nasal decongestants, monoamine oxidase
- Inability to lie flat for 90 min
- Pregnant or breast feeding