Jacksonville, Florida 32224


Purpose:

To better understand the relationship between gut barrier function and the symptomatology and pathophysiology of IBS.


Criteria:

Inclusion criteria - Age 18 to 70 years - No restrictions on Hospital Anxiety and Depression score - No abdominal surgery (except appendectomy). - Written informed consent Exclusion criteria - Females who are pregnant, breastfeeding or hysterectomized. - Use of tobacco products within the past 6 months (since nicotine may affect intestinal permeability) - Use of NSAIDs or aspirin within the past week (since NSAIDs affect intestinal permeability) - Use of oral corticosteroids within the previous 6 weeks - Ingestion of artificial sweeteners such as Splenda TM (sucralose), Nutrasweet TM (aspartame), lactulose or mannitol 2 days before the study tests begins, e.g. foods to be avoided are sugarless gyms or mints and diet soda. - Ingestion of any prescription, over the counter, or herbal medications which can affect gastrointestinal transit 7 days before the study begins. - Proton pump inhibitors. - Antibiotics for the preceding 60 days before the start of the study. - (vii) Alcohol intake beyond the recommended safe limit (<21 unites per week) - Bleeding disorders or medications that increase risk of bleeding from mucosal biopsies. - Known allergy to fluorescein - Inflammatory bowel diseases, celiac disease. - Clinically significant bradycardia with potential to interfere with procedure induced vagal tone (Investigators may be guided by a cut-off heart rate of < 50


NCT ID:

NCT02358564


Primary Contact:

Principal Investigator
Lesley Houghton, PhD
Mayo Clinic

Madhusudan Grover, MD
Email: Grover.Madhusudan@mayo.edu


Backup Contact:

Email: breen-lyles.margaret@mayo.edu
Margaret Breen-Lyles
Phone: 5072666332


Location Contact:

Jacksonville, Florida 32224
United States

Kenneth DeVault, MD
Phone: 904-953-8101
Email: DeVault.Kenneth@mayo.edu

Site Status: Recruiting


Data Source: ClinicalTrials.gov

Date Processed: November 20, 2017

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