Chaleston, South Carolina 29461


Purpose:

Ketorolac is administered as current practice to the majority of patients undergoing knee arthroscopy, the appropriate dose of ketorolac to be administered has not been evaluated.


Study summary:

Past studies have examined different doses of ketorolac administered to patients after spinal fusion surgery and found that 7.5 mg every 6 hours was as effective as 15 or 30 mg every 6 hours in decreasing postoperative pain and patient opiate consumption. Since ketorolac side effects such as gastrointestinal and surgical site bleeding seem to be dose related, utilizing a lower dose of ketorolac may be more efficacious.


Criteria:

Population: Patients scheduled for outpatient knee arthroscopy under general anesthesia with ASA physical status I-III ages 18-65 years old. All subjects will receive informed consent. Subjects will not be eligible to participate if they cannot provide informed consent. Non-English speaking patients will not be included due to the limited time and availability of translators. Inclusion Criteria: 1. Ability to consent and desire to participate in study 2. Outpatient knee arthroscopy with Dr. C. David Geier 3. ASA physical status I-III 4. 18-65 years old 5. Over 50 kg (110 pounds) 6. General anesthesia Exclusion Criteria 1. Any contraindication to receiving a non-steroidal antiinflammatory medication (including but not limited to allergy to any non-steroidal antiinflammatory medications including aspirin; chronic renal insufficiency; history of gastric ulcers, gastritis, peptic ulcers or gastrointestinal bleeding; severe volume depletion; presence of cerebrovascular bleeding or high risk of bleeding) 2. Allergy to propofol, fentanyl or hydromorphone. 3. Any chronic painful conditions requiring opioid use for over the last 6 months 4. Emergency surgery 5. Altered mental status (not oriented to place, person or time) 6. Pregnant or lactating patients 7. Patient is taking non-steroidal antiinflammatory medications (including aspirin)1 at home and took that medication on day of surgery. 8. Non-English speaking 9. Patient refusal to study 10. Patient refusal or not a candidate for general anesthesia with Laryngeal Mask Airway (LMA)


NCT ID:

NCT02181426


Primary Contact:

Principal Investigator
Sylvia H Wilson, MD
Medical University of South Carolina


Backup Contact:

N/A


Location Contact:

Chaleston, South Carolina 29461
United States

Jones
Email: joneswr@musc.edu

Site Status: Recruiting


Data Source: ClinicalTrials.gov

Date Processed: November 20, 2017

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