Expired Study
This study is not currently recruiting Study Participants on ClinicalConnection.com. If you would like to find active studies please search for clinical trials.

Rochester, Minnesota 55905


Purpose:

The purpose of this study is to find out if giving a medicine called furosemide, which is a diuretic or water pill, after colon surgery will safely shorten the patient's length of hospital stay.


Study summary:

This study will assess if administration of a loop diuretic, specifically furosemide, to achieve euvolemia can safely reduce length of stay following colorectal surgery.


Criteria:

Inclusion Criteria - All elective colorectal surgeries (CRS) utilizing the enhanced recovery pathway (ERP) - The surgery involves resection Exclusion Criteria Exclusion Criteria for Randomization: - Surgeries involving intraoperative radiation - Ileostomy closures, when performed as the only surgical intervention - Surgeries involving multiple disciplines (e.g., colorectal plus general surgery, colorectal plus gynecology surgery) except for colorectal surgeries plus ureteral stent placements. - Chronic loop diuretic therapy (i.e., bumetanide, torsemide, furosemide, ethacrynic acid) including as needed administration of such therapy - Patients receiving dialysis - Creatinine clearance, calculated by the Cockcroft-Gault equation, less than 30 mL/min. - Inpatient prior to surgery - Allergy to furosemide - Allergy to sulfa drugs if the allergy involves anaphylactic reaction - Lack of serum creatinine concentration within 3 months preceding the surgery AND diagnosis of chronic kidney disease Exclusion Criteria for Intervention (applies to both the intervention and control arm): - Patient's weight on postoperative day (POD) #1 and POD #2 is less than preoperative weight. - Blood pressure criteria: systolic blood pressure criteria less than 90 mmHg or greater than 30 mmHg below baseline on POD #1 and/or POD #2 immediately prior to administration of study drug. - Complications within 48 hours of surgery - Abscess (infected fluid collection, treated with CT drainage) - Leak (defined by CT drainage or reoperation) - Wound infection (treated with either antibiotics and/or open packing) - Bowel obstruction (treated with reoperation) - Reoperation - Hemorrhage - Weight change since admission on POD #1: > 5 kg - Acute kidney injury on POD #1 and POD#2 defined as serum creatinine (SCr) increase ≥ 0.3 mg/dL or increase to ≥ 150% to 200% (1.5- to 2-fold) from baseline


NCT ID:

NCT02351934


Primary Contact:

Principal Investigator
Ilya Danelich, PharmD, RPh
Mayo Clinic


Backup Contact:

N/A


Location Contact:

Rochester, Minnesota 55905
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: November 18, 2017

Modifications to this listing: Only selected fields are shown, please use the link below to view all information about this clinical trial.


Click to view Full Listing

This study is not currently recruiting Study Participants on ClinicalConnection.com. The form below is not enabled.