Pregnancy-associated diabetes, known as gestational diabetes mellitus (GDM), is associated
with an increased lifetime risk of developing diabetes mellitus (DM) or pre-diabetes. Up to
30% of women with GDM will continue have abnormal blood glucose tests 6 or more weeks after
delivery. Early diagnosis and treatment of continued impaired glucose metabolism or DM is
essential because serious health problems can result.
Current guidelines recommend a 75-gram, 2-hour glucose tolerance test (GTT) 6 or more weeks
after delivery for women diagnosed with GDM in order to identify those with continued DM or
impaired glucose metabolism. However, approximately half of these women do not get glucose
testing after delivery. The ability to test women while they are still hospitalized after
having a baby could greatly increase diagnosis, care and treatment of women with abnormal
Our objective is to determine if a 75-gram, 2-hour GTT administered to women with GDM two to
four days after delivery can identify those who will have an abnormal GTT at 6-12 weeks
This will be a prospective cohort study conducted at Winthrop-University Hospital. Women 18
years old or older who delivered a child or fetus within the previous 4 days at either
hospital who also were diagnosed with GDM during the pregnancy will be eligible for
participation. Women will be excluded if they have issues that would interfere with
administration of a GTT, are unable /unwilling to provide informed consent, or cannot follow
up. Anticipated enrollment will be 250 women at each study site.
While still hospitalized two to four days postpartum, subjects will undergo a 75-gram,
2-hour GTT and have blood tested for hemoglobin A1c and glucose levels. They will be
reminded to do the recommended GTT 6-12 weeks after delivery. Maternal, neonatal, and
obstetric characteristics will be collected, including the any GTT results. The results of
the in-hospital GTT will be compared to the result of the GTT taken 6-12 weeks postpartum
and tested for correlation.
- Women 18 years old or older
- Delivered a child or fetus within the previous 4 days
- Diagnosed with gestational diabetes during the pregnancy
- Unable or unwilling to provide informed consent for the study
- Unable to undergo or complete a 2-hour oral glucose tolerance test 2-4 days
- Unable or unwilling to have study follow up.