District of Columbia
Sarcopenia is an age-related loss of muscle mass that may affect over 25% of individuals
over the age of 60 and results in a 3 to 4 times increased likelihood of developing a
disability. Despite these observations, sarcopenia is rarely subject to a systematic
screening process as a part of customary geriatric care. Furthermore, when lean body mass
(LBM) is measured via dual energy X-ray absorptiometry (DXA) in older adults, it is
typically within a reactive, hospital-based, model of healthcare where muscle wasting is
only assessed after a loss of functional independence. The investigators propose an
affordable, portable screening method with ultrasound imaging to be performed in primary
The investigators long term goal is to identify individuals at risk, and intervene with
treatments that may prevent the onset of debilitating loss of muscle function in the
Purpose: The overall goal of this pilot project is to validate a rapid, portable,
cost-effective, sarcopenia identification method using diagnostic sonography. This method
would be used for screening to aid early detection, diagnosis in clinical settings, and
monitoring the effects of formal intervention. The investigators central hypothesis is that
the sonographic muscle characteristics will be significantly associated with estimates of
lean body mass (LBM) and functional status.
Research Setting: George Washington University, Exercise Science Laboratory.
Participants: Subjects will include a healthy young reference group (18 - 29 years of age)
and an older comparison group (55 - 75 years of age; n = 15 per group; approximately 50%
female), consecutively recruited from George Washington University and the surrounding
Implications/Significance: Diagnostic musculoskeletal ultrasound is a portable, inexpensive
modality suitable for bedside use or community health initiatives, and features no exposure
to low-dose radiation. It is important to note that DXA is considered a relatively low cost
procedure, and DXA-based measures may continue to be used as the standard for the sarcopenia
syndrome LBM criterion. Consequently, this study will examine if LBM values obtained with
ultrasound may serve as a viable proxy of LBM measures obtained with DXA.
The innovation in the investigators study is reflected by a proactive approach to sarcopenia
screening that is responsive to the growing shift of healthcare from hospitals to
alternative, community-based settings.
Inclusion Criteria: You are eligible to participate if:
1. You are between the ages of 18 - 29 years, or 55 - 75 years.
2. You must be able to stand comfortably for 10 minutes and walk a short distance (use
of assistive devices are acceptable).
Exclusion Criteria: You are not eligible to participate if:
1. You have a medical condition that results in edema.
2. You have had an upper or a lower extremity amputation.
3. You are, or may be, pregnant.
4. You have a body mass index (BMI) > 30.0.
Loretta DiPietro, PhD, MPH
George Washington University
Catheeja Ismail, EdD, RDMS
Phone: (202) 994-8697
Washington, District of Columbia 20052
Catheeja Ismail, EdD, RDMS
Site Status: Recruiting