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Stanford, California 94305


The purpose of this study is to investigate the ability of tofacitinib citrate, a Janus kinase inhibitor, to generate hair regrowth in patients with moderate to severe alopecia areata and its variants.

Study summary:

This study is an open-label pilot study. Participants will be treated with oral tofacitinib for 3 months.


Inclusion Criteria: - Age >= 18 years old - Diagnosis of alopecia areata with >50% scalp involvement, alopecia totalis, or alopecia universalis - Hair loss present for at least 6 months - No treatment for alopecia areata in past 2 months - No evidence of hair regrowth - Females of childbearing potential must use birth control while taking the medication and there must be a negative pregnancy test documented prior to starting the medication - Fluent in spoken and written English Exclusion Criteria: - Age <18 years old - Patients have received treatment known to affect alopecia areata within 2 months of enrolling in the study - Patients with a history of malignancy (except history of successfully treated basal cell or squamous cell carcinoma of the skin) - Patients known to be HIV or hepatitis B or C positive - Patients with positive tuberculin skin test or positive QuantiFERON TB test - Patients with leukopenia or anemia - Patients with renal or hepatic impairment - Patients with peptic ulcer disease - Patients taking immunosuppressive medications, including but not limited to prednisone, methotrexate, mycophenolate mofetil, azathioprine, tacrolimus, cyclosporine, or TNH-alpha inhibitors - Women of childbearing potential who are unable or unwilling to use birth control while taking the medication - Women who are pregnant or nursing



Primary Contact:

Principal Investigator
Anthony E Oro, M.D., Ph.D.
Stanford University

Backup Contact:


Location Contact:

Stanford, California 94305
United States

There is no listed contact information for this specific location.

Site Status: N/A

Data Source: ClinicalTrials.gov

Date Processed: March 16, 2018

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