Expired Study
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Kansas City, Missouri 64111


Purpose:

The purpose of this study is to determine the efficacy of intravenous Exenatide therapy in hyperglycemic patients admitted to the coronary intensive care unit.


Study summary:

Diabetic patients with acute myocardial infarction (MI) have particularly poor outcomes. Clinical practice guidelines from the American College of Cardiology/American Heart Association for the treatment of patients with acute coronary syndromes call for treatment to achieve preprandial glucose <110 mg/dL, a maximum daily target <180 mg/dL, and a post-discharge hemoglobin A1c <7%. Initiation of aggressive insulin therapy is also warranted to achieve blood glucose <150 mg/dL during days 0-3 and 80-110 mg/dL when possible thereafter. To date, no studies have been conducted assessing the efficacy of intravenous exenatide administration on achieving glucose lowering in hyperglycemic coronary ICU patients.


Criteria:

Inclusion Criteria: - Admission to coronary ICU - Admission blood glucose 140-299 mg/dL - Primary cardiovascular diagnosis by attending physician - Under primary care of cardiology service - Age > 18 years old - Ventilator independent - Able to provide informed consent Exclusion Criteria: - Admission blood glucose < 140 or > 300 mg/dL - Ventilator dependent - Unconscious sedation - Type 1 diabetes - Known pregnancy - Admitted to coronary ICU for right heart cath to measure hemodynamics prior to transplant - Post transplant procedure - Currently enrolled in another clinical trial - Unable to provide informed consent - Creatinine clearance < 30 mL/min - On insulin treatment except for monotherapy with long-acting basal insulin (e.g., insulin glargine [Lantus®] or detemir [Levemir®]) - Gastroparesis


NCT ID:

NCT00736229


Primary Contact:

Principal Investigator
Steven P Marso, MD
Mid America Heart Institute Saint Luke's Health System


Backup Contact:

N/A


Location Contact:

Kansas City, Missouri 64111
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: January 18, 2018

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