The aim of the proposed research is to measure the effect of drug-induced sedation on the
functional connectivity between brain regions as indicated by EEG signal transmission within
the human brain. The results of this study will help to identify the neurophysiological
correlates of changes in conscious experience that occur during drug-induced sedation.
In the proposed experiments cortical areas will be stimulated using low frequency,
low-amplitude transcranial magnetic stimulation (TMS) in healthy human subjects during
wakefulness and during drug-induced responsive sedation and unresponsive sedation.
Simultaneously, high-density electroencephalography (Hd-EEG) will be recorded to evaluate
the temporal and spatial characteristics of evoked responses and induced rhythms over the
- Healthy right-handed men
- Aged 18-35
- No metallic implants
- Younger than 18 or over the age of 35.
Robert Pearce, MD, PhD
University of Wisconsin, Madison