RATIONALE: Aerobic exercise may help prevent side effects caused by chemotherapy and help
improve heart health.
PURPOSE: This randomized clinical trial is studying the side effects of aerobic exercise and
to see how well it works in patients receiving chemotherapy for cancer.
- To determine if patients with cancer can exercise safely and routinely, under
supervision, while receiving anthracycline chemotherapy.
- To determine the magnitude of the change in the peak ventilatory oxygen uptake (VO2)
before and after completion of anthracycline chemotherapy with concurrent exercise
versus without exercise in patients with cancer.
OUTLINE: Patients are randomized to 1 of 2 intervention arms.
- Arm I (exercise): Patients undergo supervised aerobic exercise (walk or bicycle) 3 days
a week concurrently with standard anthracycline-based chemotherapy for approximately
- Arm II (non-exercise): Patients receive standard anthracycline-based chemotherapy for
approximately 18-24 weeks.
Patients undergo peak ventilatory oxygen uptake (VO_2) by exercise bike test with gas
exchange analysis at baseline and at 2 weeks after completion of anthracycline-based
- Patients with cancer scheduled to receive 4-6 courses of an anthracycline-based
- Able to pedal a stationary bicycle
- No severe hypertension (systolic blood pressure > 220 mm Hg or diastolic blood
pressure >120 mm Hg)
- No atrial fibrillation with an uncontrolled ventricular response
- No ventricular arrhythmias
- No unstable angina
- No acute myocardial infarction within the past 28 days of enrollment
- No severe valvular heart disease
- No severe (exercise-limiting) peripheral vascular disease
- No severe pulmonary disease
PRIOR CONCURRENT THERAPY:
- See Disease Characteristics