The purpose of the study is to examine glycemic and neuropsychological outcomes in very
young children with Type I diabetes who are being started on insulin pumps and to compare
their outcomes to children who are not utilizing insulin pumps. We propose to assess 40
children with IDDM under 5 years of age. 10 patients examined will be using multiple daily
injections with basal glargine, 10 will be using NPH or Lente and rapid-acting insulin, and
20 will be examined prior to and 12 months after the implementation of insulin pump therapy.
These subjects will be recruited and followed because they are currently undergoing
treatment for Type 1 diabetes. Children will be recruited based upon the insulin regimen
that they and their primary diabetes physician have chosen to utilize clinically. Insulin
regimens will not be changed by the study team. Outcome measures will examine: glycemic
outcomes (overall control, blood sugar variability), cognitive outcomes, parenting Stress,
and changes in diet.
1. Children with Type I diabetes:
2. Children must be 5 years of age or less at the time of entry into the study.
3. Children must have had a diagnosis of type I diabetes for at least 1 year at time of
4. Children must be receiving two or more insulin injections daily.
1. Children will be excluded if they have additional medical problems requiring
treatment with agents known to affect blood glucose such as steroids or
2. Children must not have any other chronic illness in addition to diabetes.