Available data suggest that obtaining adequate sleep is associated with a better ability of
the body to use carbohydrates as a source of energy and a lower risk of developing diabetes.
The sleeping pill, Eszopiclone (Lunesta), has been approved by the Food and Drug
Administration for the treatment of people who complain of trouble falling or staying
asleep. This study will examine the hypothesis that the use of Eszopiclone (Lunesta) to
improve the sleep of people with insomnia may also improve the use of sugar in their body.
Study participants will complete a set of oral and intravenous glucose (sugar) tolerance
tests, which will be performed on two separate occasions in random order: once after a week
of treatment with Eszopiclone (Lunesta) and once again after a week of receiving placebo.
- age between 35 and 64
- must have long-standing trouble falling or staying asleep
- BMI between 22 and 34 kg/m2
- sleep apnea or other sleep disorder other than insomnia
- diagnosis of diabetes requiring treatment with pills or insulin
- night or shift work
- presence of a medical condition that can disrupt sleep
- women only: irregular menstrual periods or pregnancy
- use of medications/compounds that can disrupt sleep