Expired Study
This study is not currently recruiting Study Participants on ClinicalConnection.com. If you would like to find active studies please search for clinical trials.

Mayfield Heights, Ohio 44124


This study is being done to determine if combined infusions of lidocaine and ketamine is better than a lidocaine or ketamine infusion alone, or to placebo in improving recovery after abdominal hysterectomy. Participants will be randomized into one of four groups. Evaluations will be done through walking tests, pain and fatigue questionnaires and blood tests.

Study summary:

Subjects undergoing abdominal hysterectomy surgery are randomized into one of four groups: Intravenous Lidocaine, Intravenous Ketamine, Intravenous Lidocaine and Ketamine or Placebo. Subjects will perform a six-minute walk test prior to surgery and on the second day postoperatively. After surgery and on days 1 and 2 after surgery, subjects will rate their pain. On day 1 postoperatively, subjects will rate their fatigue. On postoperative days 1 and 2 incisional pain will be analysed using von Frey filaments. Two hours after surgery, 10 ml of venous blood will be sampled for cytokine analysis. Telephone follow up will take place 6 and 12 months postoperatively to access pain and quality of life.


Inclusion Criteria: - Age greater than 18 years old and less than 75 years years old - Horizontal abdominal incision Exclusion Criteria: - Emergency or urgent procedure - Preexisting chronic pain (at any site) requiring treatment - Contraindication to any study medication (ketamine or lidocaine) - History of significant Axis I psychiatric disease (major depressive disorder, bipolar disorder, schizophrenia, etc.) - Significant hepatic (ALT or AST > 2 times normal) or renal (serum creatinine > 2 mg/dl) impairment - Seizure disorder requiring medication within past 2 years - Planned spinal or epidural anesthesia or analgesia



Primary Contact:

Principal Investigator
Martin Grady, MD
Cleveland Clinic/Hillcrest Hospital

Backup Contact:


Location Contact:

Mayfield Heights, Ohio 44124
United States

There is no listed contact information for this specific location.

Site Status: N/A

Data Source: ClinicalTrials.gov

Date Processed: March 16, 2018

Modifications to this listing: Only selected fields are shown, please use the link below to view all information about this clinical trial.

Click to view Full Listing

This study is not currently recruiting Study Participants on ClinicalConnection.com. The form below is not enabled.