This study is being done to determine if combined infusions of lidocaine and ketamine is
better than a lidocaine or ketamine infusion alone, or to placebo in improving recovery
after abdominal hysterectomy. Participants will be randomized into one of four groups.
Evaluations will be done through walking tests, pain and fatigue questionnaires and blood
Subjects undergoing abdominal hysterectomy surgery are randomized into one of four groups:
Intravenous Lidocaine, Intravenous Ketamine, Intravenous Lidocaine and Ketamine or Placebo.
Subjects will perform a six-minute walk test prior to surgery and on the second day
postoperatively. After surgery and on days 1 and 2 after surgery, subjects will rate their
pain. On day 1 postoperatively, subjects will rate their fatigue. On postoperative days 1
and 2 incisional pain will be analysed using von Frey filaments. Two hours after surgery, 10
ml of venous blood will be sampled for cytokine analysis. Telephone follow up will take
place 6 and 12 months postoperatively to access pain and quality of life.
- Age greater than 18 years old and less than 75 years years old
- Horizontal abdominal incision
- Emergency or urgent procedure
- Preexisting chronic pain (at any site) requiring treatment
- Contraindication to any study medication (ketamine or lidocaine)
- History of significant Axis I psychiatric disease (major depressive disorder, bipolar
disorder, schizophrenia, etc.)
- Significant hepatic (ALT or AST > 2 times normal) or renal (serum creatinine > 2
- Seizure disorder requiring medication within past 2 years
- Planned spinal or epidural anesthesia or analgesia