Evidence in animals shows that losartan can prevent or reverse inflammation and lung damage
due to smoking. The goal of this study is to determine whether this drug which is also used
to treat hypertension can stabilize or improve lung function in people who have from chronic
obstructive pulmonary disease (COPD).
Participants will be given either losartan in a dose of 50-100 mg per day for a period of
one year. During that time, they will have lung function tests, breathing tests, and
computed tomograms of the chest. These tests will determine whether there is inflammation
in the lung and whether there is progressive involvement of the lung with COPD.
- Adults with COPD who are either active or former smokers
- Clinical requirement or history of intolerance of angiotensin receptor blockers,
serious heart, liver, kidney, neurological disease.